An international registry for drug-induced arrhythmias
نویسندگان
چکیده
منابع مشابه
Channel structure and drug-induced cardiac arrhythmias.
E lectrical activity underlies the control of the frequency, strength, and duration of contraction of the heart. During the cardiac cycle, a regular rhythmic pattern must be established in time-dependent changes in ionic conductances to ensure events that underlie normal cardiac function. Electrical impulses, originating at the sino atrial node are conducted throughout the atria until they conv...
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Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias such as torsades de pointes. The risk evaluation of a new compound is costly and can take a long time, which often hinders the development of new drugs. Here, we establish a high-resolution, multiscale computational model to quickly assess the cardiac toxicity of new and existing drugs. The input of the mo...
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BACKGROUND The management of pediatric melanoma (PM) has largely been extrapolated from adult data. However, the behavior of PM appears to differ from its adult counterparts. Therefore, an international PM registry was created and analyzed. METHODS Twelve institutions contributed deidentified clinicopathologic and outcome data for patients diagnosed with PM from 1953 through 2008. RESULTS O...
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Precision medicine refers to new treatment and prevention strategies that take individual variability into account. Toward that end, the National Institutes of Health Precision Medicine Initiative envisions supporting a research program to encourage creative approaches to precision medicine, test them rigorously, and ultimately use them to build the evidence base needed to guide clinical practi...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2000
ISSN: 1364-8535
DOI: 10.1186/ccf-2000-webreport461